<opt>
  <data SO_accession="SO:0001895" SO_term="TFBS_ablation" description="A feature ablation whereby the deleted region includes a transcription factor binding site" label="TFBS ablation" />
  <data SO_accession="SO:0001889" SO_term="transcript_amplification" description="A feature amplification of a region containing a transcript" label="transcript amplification" />
  <data SO_accession="SO:0001907" SO_term="feature_elongation" description="A sequence variant that causes the extension of a genomic feature, with regard to the reference sequence" label="feature elongation" />
  <data SO_accession="SO:0001574" SO_term="splice_acceptor_variant" description="A splice variant that changes the 2 base region at the 3' end of an intron" label="splice acceptor variant" />
  <data SO_accession="SO:0001589" SO_term="frameshift_variant" description="A sequence variant which causes a disruption of the translational reading frame, because the number of nucleotides inserted or deleted is not a multiple of three" label="frameshift variant" />
  <data SO_accession="SO:0001819" SO_term="synonymous_variant" description="A sequence variant where there is no resulting change to the encoded amino acid" label="synonymous variant" />
  <data SO_accession="SO:0001060" SO_term="sequence_variant" description="A sequence_variant is a non exact copy of a sequence_feature or genome exhibiting one or more sequence_alteration" label="sequence variant" />
  <data SO_accession="SO:0001578" SO_term="stop_lost" description="A sequence variant where at least one base of the terminator codon (stop) is changed, resulting in an elongated transcript" label="stop lost" />
  <data SO_accession="SO:0002169" SO_term="splice_polypyrimidine_tract_variant" description="A sequence variant that falls in the polypyrimidine tract at 3' end of intron between 17 and 3 bases from the end (acceptor -3 to acceptor -17)" label="splice polypyrimidine tract variant" />
  <data SO_accession="SO:0001631" SO_term="upstream_gene_variant" description="A sequence variant located 5' of a gene" label="upstream gene variant" />
  <data SO_accession="SO:0001968" SO_term="coding_transcript_variant" description="A transcript variant of a protein coding gene" label="coding transcript variant" />
  <data SO_accession="SO:0001621" SO_term="NMD_transcript_variant" description="A variant in a transcript that is the target of NMD" label="NMD transcript variant" />
  <data SO_accession="SO:0001891" SO_term="regulatory_region_amplification" description="A feature amplification of a region containing a regulatory region" label="regulatory region amplification" />
  <data SO_accession="SO:0001782" SO_term="TF_binding_site_variant" description="A sequence variant located within a transcription factor binding site" label="TF binding site" />
  <data SO_accession="SO:0001583" SO_term="missense_variant" description="A sequence variant, that changes one or more bases, resulting in a different amino acid sequence but where the length is preserved" label="missense variant" />
  <data SO_accession="SO:0001627" SO_term="intron_variant" description="A transcript variant occurring within an intron" label="intron variant" />
  <data SO_accession="SO:0001894" SO_term="regulatory_region_ablation" description="A feature ablation whereby the deleted region includes a regulatory region" label="regulatory region ablation" />
  <data SO_accession="SO:0001892" SO_term="TFBS_amplification" description="A feature amplification of a region containing a transcription factor binding site" label="TFBS amplification" />
  <data SO_accession="SO:0002019" SO_term="start_retained_variant" description="A sequence variant where at least one base in the start codon is changed, but the start remains" label="start retained variant" />
  <data SO_accession="SO:0001632" SO_term="downstream_gene_variant" description="A sequence variant located 3' of a gene" label="downstream gene variant" />
  <data SO_accession="SO:0001619" SO_term="non_coding_transcript_variant" description="A transcript variant of a non coding RNA gene" label="non coding transcript variant" />
  <data SO_accession="SO:0001623" SO_term="5_prime_UTR_variant" description="A UTR variant of the 5' UTR" label="5 prime UTR variant" />
  <data SO_accession="SO:0001575" SO_term="splice_donor_variant" description="A splice variant that changes the 2 base region at the 5' end of an intron" label="splice donor variant" />
  <data SO_accession="SO:0001818" SO_term="protein_altering_variant" description="A sequence_variant which is predicted to change the protein encoded in the coding sequence" label="protein altering variant" />
  <data SO_accession="SO:0001822" SO_term="inframe_deletion" description="An inframe non synonymous variant that deletes bases from the coding sequence" label="inframe deletion" />
  <data SO_accession="SO:0001792" SO_term="non_coding_transcript_exon_variant" description="A sequence variant that changes non-coding exon sequence in a non-coding transcript" label="non coding transcript exon variant" />
  <data SO_accession="SO:0001626" SO_term="incomplete_terminal_codon_variant" description="A sequence variant where at least one base of the final codon of an incompletely annotated transcript is changed" label="incomplete terminal codon variant" />
  <data SO_accession="SO:0001566" SO_term="regulatory_region_variant" description="A sequence variant located within a regulatory region" label="regulatory region variant" />
  <data SO_accession="SO:0002012" SO_term="start_lost" description="A codon variant that changes at least one base of the canonical start codon" label="start lost" />
  <data SO_accession="SO:0001893" SO_term="transcript_ablation" description="A feature ablation whereby the deleted region includes a transcript feature" label="transcript ablation" />
  <data SO_accession="SO:0001580" SO_term="coding_sequence_variant" description="A sequence variant that changes the coding sequence" label="coding sequence variant" />
  <data SO_accession="SO:0001630" SO_term="splice_region_variant" description="A sequence variant in which a change has occurred within the region of the splice site, either within 1-3 bases of the exon or 3-8 bases of the intron" label="splice region variant" />
  <data SO_accession="SO:0001906" SO_term="feature_truncation" description="A sequence variant that causes the reduction of a genomic feature, with regard to the reference sequence" label="feature truncation" />
  <data SO_accession="SO:0001624" SO_term="3_prime_UTR_variant" description="A UTR variant of the 3' UTR" label="3 prime UTR variant" />
  <data SO_accession="SO:0001620" SO_term="mature_miRNA_variant" description="A transcript variant located with the sequence of the mature miRNA" label="mature miRNA variant" />
  <data SO_accession="SO:0001628" SO_term="intergenic_variant" description="A sequence variant located in the intergenic region, between genes" label="intergenic variant" />
  <data SO_accession="SO:0001587" SO_term="stop_gained" description="A sequence variant whereby at least one base of a codon is changed, resulting in a premature stop codon, leading to a shortened transcript" label="stop gained" />
  <data SO_accession="SO:0002170" SO_term="splice_donor_region_variant" description="A sequence variant that falls in the region between the 3rd and 6th base after splice junction (5' end of intron)." label="splice donor region variant" />
  <data SO_accession="SO:0001787" SO_term="splice_donor_5th_base_variant" description="A sequence variant that causes a change at the 5th base pair after the start of the intron in the orientation of the transcript" label="splice donor 5th base variant" />
  <data SO_accession="SO:0001821" SO_term="inframe_insertion" description="An inframe non synonymous variant that inserts bases into in the coding sequence" label="inframe insertion" />
  <data SO_accession="SO:0001567" SO_term="stop_retained_variant" description="A sequence variant where at least one base in the terminator codon is changed, but the terminator remains" label="stop retained variant" />
</opt>
