[{"start":41240915,"input":"17:g.41240915A>G","id":"17:g.41240915A>G","assembly_name":"GRCh37","allele_string":"A/G","end":41240915,"most_severe_consequence":"intron_variant","seq_region_name":"17","colocated_variants":[{"seq_region_name":"17","start":41240915,"phenotype_or_disease":1,"end":41240915,"frequencies":{"G":{"gnomadg_fin":0.0844,"eas":0,"gnomadg_eas":0.000578,"gnomadg_remaining":0.05298,"gnomadg_sas":0.01283,"eur":0.0596,"gnomadg":0.04547,"gnomadg_asj":0.08367,"gnomadg_amr":0.03944,"gnomadg_mid":0.05102,"af":0.0218,"gnomadg_ami":0.01645,"gnomadg_nfe":0.06539,"afr":0.003,"sas":0.0133,"gnomadg_afr":0.01159,"amr":0.0461}},"clin_sig":["benign"],"var_synonyms":{"ClinVar":["RCV000191375","VCV000209430"]},"clin_sig_allele":"G:benign","id":"rs8176163","allele_string":"A/G","strand":1}],"transcript_consequences":[{"transcript_id":"ENST00000309486","biotype":"protein_coding","hgnc_id":1100,"strand":-1,"gene_id":"ENSG00000012048","gene_symbol_source":"HGNC","consequence_terms":["intron_variant"],"gene_symbol":"BRCA1","variant_allele":"G","impact":"MODIFIER"},{"impact":"MODIFIER","variant_allele":"G","gene_symbol":"BRCA1","strand":-1,"hgnc_id":1100,"gene_symbol_source":"HGNC","gene_id":"ENSG00000012048","consequence_terms":["intron_variant"],"transcript_id":"ENST00000346315","biotype":"protein_coding"},{"transcript_id":"ENST00000351666","biotype":"protein_coding","hgnc_id":1100,"strand":-1,"gene_id":"ENSG00000012048","consequence_terms":["intron_variant"],"gene_symbol_source":"HGNC","gene_symbol":"BRCA1","impact":"MODIFIER","variant_allele":"G"},{"strand":-1,"hgnc_id":1100,"gene_symbol_source":"HGNC","consequence_terms":["intron_variant"],"gene_id":"ENSG00000012048","transcript_id":"ENST00000352993","biotype":"protein_coding","variant_allele":"G","impact":"MODIFIER","gene_symbol":"BRCA1"},{"transcript_id":"ENST00000354071","biotype":"protein_coding","strand":-1,"hgnc_id":1100,"gene_symbol_source":"HGNC","consequence_terms":["intron_variant"],"gene_id":"ENSG00000012048","gene_symbol":"BRCA1","variant_allele":"G","impact":"MODIFIER"},{"biotype":"protein_coding","transcript_id":"ENST00000357654","consequence_terms":["intron_variant"],"gene_id":"ENSG00000012048","gene_symbol_source":"HGNC","strand":-1,"hgnc_id":1100,"gene_symbol":"BRCA1","impact":"MODIFIER","variant_allele":"G"},{"flags":["cds_start_NF"],"biotype":"non_stop_decay","transcript_id":"ENST00000412061","consequence_terms":["downstream_gene_variant"],"gene_symbol_source":"HGNC","gene_id":"ENSG00000012048","hgnc_id":1100,"strand":-1,"distance":4672,"gene_symbol":"BRCA1","impact":"MODIFIER","variant_allele":"G"},{"gene_symbol_source":"HGNC","consequence_terms":["intron_variant","NMD_transcript_variant"],"gene_id":"ENSG00000012048","strand":-1,"hgnc_id":1100,"biotype":"nonsense_mediated_decay","transcript_id":"ENST00000461221","impact":"MODIFIER","variant_allele":"G","gene_symbol":"BRCA1"},{"impact":"MODIFIER","variant_allele":"G","gene_symbol":"BRCA1","hgnc_id":1100,"strand":-1,"gene_symbol_source":"HGNC","gene_id":"ENSG00000012048","consequence_terms":["intron_variant"],"transcript_id":"ENST00000461574","biotype":"protein_coding","flags":["cds_start_NF","cds_end_NF"]},{"transcript_id":"ENST00000467274","biotype":"retained_intron","hgnc_id":1100,"strand":-1,"consequence_terms":["downstream_gene_variant"],"gene_id":"ENSG00000012048","gene_symbol_source":"HGNC","gene_symbol":"BRCA1","distance":2200,"impact":"MODIFIER","variant_allele":"G"},{"impact":"MODIFIER","variant_allele":"G","gene_symbol":"BRCA1","strand":-1,"hgnc_id":1100,"gene_symbol_source":"HGNC","gene_id":"ENSG00000012048","consequence_terms":["intron_variant"],"transcript_id":"ENST00000468300","biotype":"protein_coding"},{"strand":-1,"hgnc_id":1100,"gene_id":"ENSG00000012048","consequence_terms":["downstream_gene_variant"],"gene_symbol_source":"HGNC","transcript_id":"ENST00000470026","biotype":"protein_coding","flags":["cds_end_NF"],"variant_allele":"G","impact":"MODIFIER","gene_symbol":"BRCA1","distance":4686},{"gene_symbol":"BRCA1","variant_allele":"G","impact":"MODIFIER","biotype":"protein_coding","transcript_id":"ENST00000471181","gene_symbol_source":"HGNC","consequence_terms":["intron_variant"],"gene_id":"ENSG00000012048","hgnc_id":1100,"strand":-1},{"gene_symbol":"BRCA1","distance":4688,"impact":"MODIFIER","variant_allele":"G","transcript_id":"ENST00000477152","flags":["cds_end_NF"],"biotype":"protein_coding","hgnc_id":1100,"strand":-1,"gene_symbol_source":"HGNC","consequence_terms":["downstream_gene_variant"],"gene_id":"ENSG00000012048"},{"gene_symbol":"BRCA1","variant_allele":"G","impact":"MODIFIER","transcript_id":"ENST00000478531","biotype":"protein_coding","flags":["cds_end_NF"],"strand":-1,"hgnc_id":1100,"gene_symbol_source":"HGNC","consequence_terms":["intron_variant"],"gene_id":"ENSG00000012048"},{"consequence_terms":["intron_variant"],"gene_id":"ENSG00000012048","gene_symbol_source":"HGNC","strand":-1,"hgnc_id":1100,"flags":["cds_start_NF","cds_end_NF"],"biotype":"protein_coding","transcript_id":"ENST00000484087","variant_allele":"G","impact":"MODIFIER","gene_symbol":"BRCA1"},{"transcript_id":"ENST00000487825","flags":["cds_start_NF","cds_end_NF"],"biotype":"protein_coding","strand":-1,"hgnc_id":1100,"gene_symbol_source":"HGNC","gene_id":"ENSG00000012048","consequence_terms":["intron_variant"],"gene_symbol":"BRCA1","impact":"MODIFIER","variant_allele":"G"},{"gene_symbol":"BRCA1","variant_allele":"G","impact":"MODIFIER","transcript_id":"ENST00000491747","biotype":"protein_coding","strand":-1,"hgnc_id":1100,"gene_symbol_source":"HGNC","consequence_terms":["intron_variant"],"gene_id":"ENSG00000012048"},{"gene_symbol":"BRCA1","variant_allele":"G","impact":"MODIFIER","transcript_id":"ENST00000493795","biotype":"protein_coding","hgnc_id":1100,"strand":-1,"consequence_terms":["intron_variant"],"gene_symbol_source":"HGNC","gene_id":"ENSG00000012048"},{"strand":-1,"hgnc_id":1100,"gene_id":"ENSG00000012048","gene_symbol_source":"HGNC","consequence_terms":["intron_variant"],"transcript_id":"ENST00000493919","biotype":"protein_coding","flags":["cds_end_NF"],"variant_allele":"G","impact":"MODIFIER","gene_symbol":"BRCA1"},{"gene_symbol":"BRCA1","impact":"MODIFIER","variant_allele":"G","biotype":"protein_coding","transcript_id":"ENST00000586385","consequence_terms":["intron_variant"],"gene_symbol_source":"HGNC","gene_id":"ENSG00000012048","strand":-1,"hgnc_id":1100},{"impact":"MODIFIER","variant_allele":"G","gene_symbol":"BRCA1","gene_id":"ENSG00000012048","gene_symbol_source":"HGNC","consequence_terms":["intron_variant"],"hgnc_id":1100,"strand":-1,"biotype":"protein_coding","transcript_id":"ENST00000591534"},{"variant_allele":"G","impact":"MODIFIER","gene_symbol":"BRCA1","gene_symbol_source":"HGNC","gene_id":"ENSG00000012048","consequence_terms":["intron_variant"],"strand":-1,"hgnc_id":1100,"biotype":"protein_coding","transcript_id":"ENST00000591849"}],"strand":1}]